Edwin Wang Lab

Cancer Systems Biology and Bioinformatics



Edwin Wang (ed), Cancer Systems Biology, CRC Press, 2010, (The first book of the cancer systems biology field), In AmazonCRC PressWikiGoogle Book 


Research Articles and Reviews  

You et al., The multivalent histone binder BRPF1 is essential for development of fetal hematopoietic stem cells, J Clinical Investigations (JCI), in press, 2016

Gao et al., Identification and construction of combinatory cancer-hallmark-based gene signature sets that predict recurrence and chemotherapy benefit in stage II colorectal cancerJAMA Oncology, On-line (PDF)Supplemental Material2015

Schweitzer et al., Characterization of the NPC1L1 gene and proteome from an exceptional responder to ezetimibe, Atherosclerosis, online published, 2015

Phuong et al., Molecular Characterization of the Vasculature of Patients with Infiltrating Ductal Carcinoma Generates a Gene Signature Predictive of Breast Cancer Survival, Journal of Cancer Biology and Research, 2015

You et al., The lysine acetylation activator Brpf1 governs dentate gyrus development through neural progenitors and stem cells, PLoS Genetics, 11: e1005034, 2015

Hill et al., Glycoproteomic Comparison of Clinical Triple-Negative and Luminal Breast Tumors, J. Proteome Res, 14: 1376-1388, 2015

 You et al., The chromatin regulator Brpf1 regulates embryo development and cell proliferation, J. Biol Chem, in press, 2015

 You et al., Deficiency of the multivalent chromatin regulator Brpf1 causes abnormal brain development, J. Biol Chem, 290: 7114-7129, 2015

 Edwin Wang* et al., Predictive Genomics: A cancer hallmark network framework for predicting tumor clinical phenotype using genome sequencing data, Seminar in Cancer Biology (Invited review), 2014, PDF,

 Masoudi-Nejad and Edwin WangCancer modeling and network biology: Accelerating toward personalized medicine, Seminar in Cancer Biology (Invited review), 2014

 Masoudi-Nejad, .. and Edwin Wang, Cancer systems biology and modeling: Microscopic scale and multiscale approaches, Seminar in Cancer Biology (Invited review), 2014

Zaman et al., Proteomic-Coupled-Network Analysis of T877A-Androgen Receptor Interactomes Can Predict Clinical Prostate Cancer Outcomes between White (Non-Hispanic) and African-American Groups, PLoS One, e113190,  2014

Zaman N. …. Edwin Wang*, Signaling network assessment of mutations and copy number variations predict breast cancer subtype-specific drug targets, Cell Reports (a new Cell sister journal), 5:216-223, 2013, Paper in Cell Press,

 Edwin Wang* et al., Cancer systems biology in the genome sequencing era: Part 1, dissecting and modeling of tumor clones and their networks, Seminar in Cancer Biology (Invited Review), 23:279-285, 2013, PDF, PMID:23791722

  Edwin Wang* et al., Cancer systems biology in the genome sequencing era: Part 2, evolutionary dynamics of tumor clonal networks and drug resistance, Seminar in Cancer Biology (Invited Review), 23:286-292, 2013, PDF, PMID:23792107

  Edwin Wang, Understanding genomic alterations in cancer genomes using an integrative network approach, Cancer Letters (Invited Review), 340: 261-9, 2013,PDFPMID:23266571 

Cohen,.. Edwin Wang, .. et al., A Mass spectrometry-based plasma protein panel targeting the tumor microenvironment in patients with breast cancer, J. Proteomics, 81:135-47, 2013, paper link,

Li L., Fu C., Tibiche C., Kaneko T., Schiller M., Li S., Edwin Wang, The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer, Genome Research, 22:1222-30, 2012, Paper in Genome Res

 Qiu C, Wang D, Edwin Wang and Cui Q., An upstream interacting context based framework for the computational inference of microRNA functions, Mol Biosyst, 8:1492-8, 2012

Ren, .. Edwin Wang, .. et al, Target of rapamycin signaling regulates metabolism, growth, and life span in Arabidopsis, Plant Cell, 24:2850-74, 2012 

Paliouuras, .. Edwin Wang.. et al., Dynamic rewiring of the Androgen Receptor interaction networks correlates with prosate cancer clinical outcomes, Integrative Biology, 3:1020-1032, 2011, PDF,PMID:21901193

Xiang, .. Edwin Wang, .. et al, POPCORN functions in the auxin pathway to regulate embryonic body plan and meristem organization in arabidopsis, Plant Cell, 23:4348-67, 2011

 Cloutier M and Wang Edwin, Dynamic modeling and analysis of cancer cellular network motifs, Integrative Biology, (Invited review) 3:724-732, 2011, PDFPMID:21674097

Hill, .. Edwin Wang, .. et al., Identification of vascular breast tumor markers by laser capture microdissection and label-free LC-MS, Journal of Proteome Research, 10:2479-2493, 2011, paper link,

 Xiang, .. Edwin Wang, .. et al., Genome-wide analysis reveals gene expression and metabolic network dynamics during embryo development in Arabidopsis, Plant Physiol, 156:346-356, 2011

 Venglat P… Edwin Wang, .. et al., Gene expression analysis of flax seed development, BMC Plant Biology, 11: 74, 2011

Li and Wang, A Multiple Survival Screening algorithm (MSS) for identifying high-quality cancer prognostic markers (Protocol), doi:10.1038/protex.2011.211, 2011

Li. J., Lenferink, AE., Cantin, C., Purisima EO., O’Connor-McCourt, MD., and Edwin Wang, Identification of high quality cancer prognostic markers and metastasis network modules, Nature Communications, 1:34, 2010, Paper in Nature Communications

Qiu C., Wang J., Yao P., Edwin Wang, Cui Q., microRNA evolution in a human transcription factor and microRNA regulatory network, BMC Systems Biology, 4:90, 2010 (Highly Accessed noted by the journal website),

Lenferink, AE., Cantin, C., Nantel, A., Edwin Wang, Durocher, Y., Banville, M., Collins, C., Wilson, MR., O’Connor-McCourt, MD., Transcriptome profiling of a TGF-beta-induced epithelial-to-mesenchymal transition reveals extracellular clusterin as a target for therapeutic antibodies, Oncogene, 29:831–844, 2010

Fu, C., Li, J., Edwin Wang, Signaling network analysis of ubiquitin-mediated proteins suggests correlations between the 26S proteasome and tumor progression, Molecular BioSystems, 5:1809-1816, 2009, paper link, 

 Cui, Q., Purisima EO., Wang, Edwin, Protein evolution on a human signaling network, BMC Systems Biology, 3:21, 2009 (Highly Accessed noted by the journal website), paper in BMC Systems Biology

 Wang D, Lu M, Miao J, Li T, Wang Edwin, Cui Q, Cepred: Predicting the co-expression patterns of the human intronic microRNAs with their host genes. PLoS ONE 4: e4421, 2009

 Yang, H., Xiang, D., Venglat, SP., Cao, Y., Wang, Edwin, Selvaraj, G., and Datla, R., PolA2 is required for embryo development in Arabidopsis, Botany, 87:626-634, 2009, 

 Tibiche, C. and Edwin Wang, MicroRNA regulatory patterns on the human metabolic network, The Open Systems Biology Journal, 1:1-8, 2008, Paper in the Systems Biology Journal

Cui Q, Ma Y, Jaramillo M, Bari H, Awan A, Yang S, Zhang S, Liu L, Lu M, O'Connor-McCourt M, Purisima EO, Edwin Wang, A map of human cancer signaling, (Nature/EMBO) Molecular Systems Biology, 3:152, 2007, Paper in Molecular Systems Biology (MSB)

 Awan A, Bari H, Yan F, Moksong S, Yang S, Chowdhury S, Cui Q, Yu Z, Purisima EO, Edwin Wang, Regulatory network motifs and hotspots of cancer genes in a mammalian cellular signaling network, IET Systems Biology, 1:292-297, 2007, PDF

Cui Q, Yu Z, Purisima EO, Edwin Wang, MicroRNA regulation and cross-species variation of gene expression, Trends Genet., 23:372-375, 2007, PDFPaper in Cell Press

Edwin Wang*, Lenferink A, O'Connor-McCourt M., Cancer systems biology: exploring cancer-associated genes on cellular networks (invited review), Cellular and Molecular Life Sciences (CMLS), 64:1752-1762, 2007, PDF

Yu Z, Jian Z, Shen SH, Purisima E, Edwin Wang, Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos, Nuclei Acids Research, 35:152-164, 2007 (Selected by Faculty of Biology 1000), Paper in the journal

Yu Z, Li Z, Jolicoeur N, Zhang L, Fortin Y, Edwin Wang, Shen SH., Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers, Nuclei Acids Research, 35:4535-4541, 2007, Paper in the journal

Cui Q, Yu Z, Pan Y, Purisima EO, Edwin Wang, MicroRNAs preferentially target the genes with high transcriptional regulation complexity, Biochem Biophys Res Commun., 352:733-738, 2007, PDF

Cui Q, Yu Z, Purisima EO, Edwin Wang, Principles of microRNA regulation of a human cellular signaling network, (Nature/EMBO) Molecular Systems Biology, 2:46, 2006, Paper in Molecular Systems Biology (MSB)

Edwin Wang*, Purisima E., Network motifs are enriched with transcription factors whose transcripts have short half-lives, Trends Genet. 21:492-495, 2005, PDFPaper in Cell Press

Braun, B.... Edwin Wang ...et al., 2005, A human-curated annotation of the Candida albicans genome, PLoS Genet. 1: e1, 2005


Editorial Boards 

PLoS Computational Biology, Website

Scientific Reports, Website 

BMC Systems Biology, Website 

Frontiers in Plant ScienceWebsite 

Genomics, Proteomics and Bioinformatics, Website 

Animal Cells and Systems, Website 

Annals of Translational Medicine, Website



Edwin Wang, PhD

AISH Chair Professor in Cancer Genomics/informatics
University of Calgary Cumming School of Medicine
Center for Health Genomics and Informatics
Department of Biochemistry and Molecular Biology
Department of Medical Genetics
Department of Oncology
Alberta Children's Hospital Research Institute
Arnie Charbonneau Cancer Research Institute
O'Brien Institute of Public Health 
Calgary, Canada
Adjunct Professor, Department of Medicine
McGill University, Montreal, Canada